Cancer Hotspot Mutation Panel

The Ion AmpliSeq™ Cancer Hotspot Mutation Panel v2 allows interrogation of hotspot regions of 50 oncogenes and tumor suppressor genes, with wide coverage of the KRAS, BRAF, and EGFR genes. This assay requires only 10 ng of DNA enabling sequencing of challenging samples such as FFPE.

JAK3 ABL1 EZH2 PTEN
IDH2 AKT1 FBXW7 PTPN11
KDR ALK FGFR1 RB1
KIT APC FGFR2 RET
KRAS ATM FGFR3 SMAD4
MET BRAF FLT3 SMARCB1
MLH1 CDH1 GNA11 SMO
MPL CDKN2A GNAS SRC
NOTCH1 CSF1R GNAQ STK11
NPM1 CTNNB1 HNF1A TP53
NRAS EGFR HRAS VHL
PDGFRA ERBB2 IDH1  
PIK3CA ERBB4 JAK2