Mass Cytometry Services

Sirona Dx is a pioneer in the development of high parameter assays for proteomic single-cell profiling using CyTOF® technology.

Our extensive experience in the design and support of clinical studies with CyTOF will ensure you achieve the most informative study outcomes.  We rely on methods and approaches that minimize sources of technical variation including workflows that allow for the simple and convenient collection of whole blood samples rather than PBMCs. This simplifies processing requirements and the need for elaborate expertise at the site of sample collection. Samples can then be shipped on dry ice from sites worldwide to our CLIA accredited facility in Portland, Oregon for processing and data acquisition. 

Clients may select a pre-designed CyTOF assay or may leverage our custom panel development expertise to create an assay that meets their unique requirements.

Our comprehensive Mass Cytometry service includes:

o Panel design

o Custom antibody conjugation and verification

o Panel optimization and validation (if required)

o Assembly of sample collection kits

o Sample processing

o Data acquisition

o Data analysis pipeline to help you:

• Identify & quantify cell populations and functional states
• Evaluate targeted biomarkers for preclinical and clinical samples 
• Classify patients based on biomarkers. 

We encourage you to contact us with your requirements and the Sirona Dx team will discuss the options and help settle on the best approach for your study. 

For suspension Mass Cytometry:

•• Use one or more of the pre-designed panels listed below or

•• We can develop a customized panel to perfectly match your needs. 

Please contact us for more information.

 CyTOF Pre-designed panels include:

• Maxpar® Human Immune Monitoring Panel, 29 Markers  

• Maxpar® Human PB Basic I Phenotyping Panel, 7 Markers 

• Maxpar® Mouse Sp/LN Basic Phenotyping Panel, 6 Markers  

• Maxpar® Human T-Cell Phenotyping Panel, 16 Markers  

• Maxpar® Human PB Phenotyping Panel, 17 Markers  

• Maxpar® Mouse Sp/LN Phenotyping Panel, 16 Markers  

• Maxpar® Human T-Cell Phenotyping EX Panel, 10 Markers  

• Maxpar® Human Intracellular Cytokine I Panel, 11 Markers  

• Maxpar® Signaling I Panel, 7 Markers 

• Maxpar® Mouse Intracellular Cytokine I Panel, 8 Markers 

• Maxpar® Human HSPC PhenoEXPanel, 7 Markers  

• Maxpar® Cell Cycle Panel , 5 Markers  

• Maxpar® Human B-Cell Phenotyping Panel, 12 Markers 

• Maxpar® Human PB Basic II Phenotyping Panel, 7 Markers 

• Maxpar® Human AML Phenotyping Panel, 15 Markers

• Maxpar® Human Mono/Macro Phenotyping Panel, 15 Markers 

• Maxpar® Human Helper T Cell Phenotyping Panel, 15 Markers 

• Maxpar® Human Treg Phenotyping Panel Kit, 13 Markers 

• Maxpar® Human ES/iPS Phenotyping Panel 

• Maxpar Human T Cell Immuno-Oncology EX Panel, 8 markers 

• Maxpar Complete Human T Cell Immuno-Oncology Panel  

• Maxpar Basic Human T Cell Immuno-Oncology Panel