Sirona Dx pioneered Imaging Mass Cytometry™ applications for biopharma launching the world's first commercial CRO service in 2018. A leading edge technology, IMC enables highly multiplexed immunohistochemistry (mIHC) with simultaneous detection of up to 38 protein markers in the same tissue section with subcellular, single cell resolution.
Our IMC service utilizes the Hyperion™ Imaging platform and metal tagged antibodies combined with powerful image analysis software and industry leading technical expertise to help our clients characterize the tissue microenvironment, evaluate targeted biomarkers for preclinical and clinical samples and classify patients based on tissue biomarkers.
Our Comprehensive End to End service includes:
o Antibody panel design (up to 38 markers)
o Custom antibody conjugation and verification
o Panel Optimization
o Panel Validation (if required)
o Tissue processing: sectioning, pretreatment and stainingo Image acquisition using precise, directed laser ablation & detection with CyTOF® technology
o Image analysis and advanced bioinformatics to
An optimized IMC panel that enables comprehensive analysis of the tumor microenvironment at a sub-cellular resolution. Use as is, or modify to accelerate the development of a custom panel.