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Next Generation Sequencing

Sirona Dx harnesses Ion Torrent PGM systems to generate large amounts of high-quality Next Generation Sequencing (NGS) data including from challenging clinical samples such as FFPE.

Ion Torrent Next Generation Sequencing (NGS) utilizes a semiconductor-based, sequencing-by-synthesis technology and emulsion PCR (emPCR) to measures the H+ ions released during base incorporation.

Bases of small fragments of DNA are sequentially identified from signals emitted as each fragment is re-synthesized from a DNA template strand. NGS extends this process across millions of reactions in a massively parallel fashion, rather than being limited to a single or a few DNA fragments.


NGS Applications include:

  • Targeted sequencing for DNA and RNA
  • Exome sequencing, enabling identification of single nucleotide variants (SNVs) and small insertions and deletions (indels)
  • Transcriptome sequencing (RNA sequencing can quantitate changes in  gene expression, as well as detect fusion transcripts from chromosomal  rearrangements)
  • Genome sequencing, including de novo sequencing, bacterial typing, and viral typing
  • Aneuploidy detection (Large chromosomal duplications or deletions and copy number variations (CNVs))
  • Epigenetic Applications (Chromatin Immunoprecipitation sequencing).
  • Microbial Population Analysis, including metagenomics and viral, bacterial, and yeast genome sequencing
Ion Torrent S5

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4640 Southwest Macadam Avenue,
Portland, Oregon 97239


Monday – Friday: 8:00am – 6:00pm PST
Saturday – Sunday: Closed