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Nanostring CosMx

Sirona Dx is the first CRO to provide access to the latest spatial multiomics 3D imaging technology from Nanostring.

Our CosMx spatial imaging service utilizes the CosMx platform to achieve multiomic, multiplex, subcellular resolution with high sensitivity from any tissue sample type.

Capabilities

  • Multiomic: RNA + protein detection
  • Multiplex: 1000 RNAs, 68 proteins
  • Subcellular: ~50 nm resolution in x, y plane
  • Sensitivity: 1-2 copies RNA per cell, multiple probes/gene
  • Samples: diverse types including FFPE, fresh frozen, TMA and organoids

Content

  • 1000-Plex RNA Human Universal Cell Characterization Panel
    • cell typing, cell-cell interaction analysis, and more in a wide range of human tissues and disease states, + up to 50 custom targets
  • 100-Plex RNA Human Immuno-oncology Panel
    • cell typing of key immune and stromal cells and evaluation of immune infiltration and tumor microenvironments, + up to 10 custom targets
  • 1000-Plex RNA Mouse Neuroscience Panel
    • cell typing, cell-cell interaction analysis, and more in mouse brain and other neuronal tissues, + up to 10 custom targets
  • 68-Plex Protein Human Protein Assays
    • cell profiling of immune and non-immune cells, including T cells, B cells, macrophages, NK cells, epithelia and stroma
CosMx-Analysis
CosMx-Analysis

Our CosMx spatial imaging service utilizes the CosMx platform to achieve multiomic, multiplex, subcellular resolution with high sensitivity from any tissue sample type.

Capabilities

  • Multiomic: RNA + protein detection
  • Multiplex: 1000 RNAs, 68 proteins
  • Subcellular: ~50 nm resolution in x, y plane
  • Sensitivity: 1-2 copies RNA per cell, multiple probes/gene
  • Samples: diverse types including FFPE, fresh frozen, TMA and organoids

Content

  • 1000-Plex RNA Human Universal Cell Characterization Panel
    • cell typing, cell-cell interaction analysis, and more in a wide range of human tissues and disease states, + up to 50 custom targets
  • 100-Plex RNA Human Immuno-oncology Panel
    • cell typing of key immune and stromal cells and evaluation of immune infiltration and tumor microenvironments, + up to 10 custom targets
  • 1000-Plex RNA Mouse Neuroscience Panel
    • cell typing, cell-cell interaction analysis, and more in mouse brain and other neuronal tissues, + up to 10 custom targets
  • 68-Plex Protein Human Protein Assays
    • cell profiling of immune and non-immune cells, including T cells, B cells, macrophages, NK cells, epithelia and stroma
CosMx-Analysis2

Comprehensive End to End Service Includes:

  • Assay customization
  • Custom conjugation & verification
  • Multiplex Assay Optimization
  • Slide Staining
  • Advanced Bioinformatics Analysis

Applications

  • Biomarker discovery and development
  • Immuno-oncology
  • Inflammatory and autoimmune diseases
  • Neuro-immunology
  • Characterization of tissue microenvironment
  • Therapeutic response
  • Drug safety and toxicity
  • Oncology

Please reach us at [email protected] for more information

Contact Us

Address

4640 Southwest Macadam Avenue,
Portland, Oregon 97239

Hours

Monday – Friday: 8:00am – 6:00pm PST
Saturday – Sunday: Closed