Welcome
The I-O Clinical Service Laboratory
The I-O Clinical Service Laboratory The I-O Clinical Service Laboratory The I-O Clinical Service LaboratoryFind out how we can accelerate your drug discovery and development programs
Our Services
Featured Platforms & Services
Mass Cytometry (CyTOF®) and Imaging Mass Cytometry (IMC™)
We have embraced mass cytometry platforms from Fluidigm to support high parameter protein profiling assays of individual cells in suspension (Helios™) as well as multiplex tissue imaging (Hyperion™).
We utilize state-of-the-art CyTOF technology to help you maximize results from precious samples and translate new discoveries into better clinical outcome!
Immune Portrait™ TME 34+5
The World’s First and Only Full Service Imaging Mass Cytometry (IMC) I-O panel that enables comprehensive analysis of the tumor microenvironment (TME):
• Visualize 34-biomarker in a single tissue section.
• Simultaneously identify Stromal & Vascular cells, Adaptive Immune cells and Innate Immune cells.
• Profile markers for immune checkpoint proteins, T cell exhaustion and functional state markers.
• Customizable – add 5 markers of your choice
NanoStrings Multiplexed RNA, miRNA & DNA, Single Molecule Counting with Digital Barcodes Technology
The nCounter® platform provides a cost-effective solution for multiplex analysis of up to 800 RNA, miRNA, DNA, or protein targets. without amplification, cDNA conversion or library prep. immuno oncology
Targeted Sequencing
Sirona Dx is an Ion Torrent Certified Service Provider, offering an extensive suite of Next Generation Sequencing capabilities with the Ion PGM and Proton systems.
Targeted sequencing enables the interrogation of specific genomic regions in a high throughput and cost-effective manner. immuno oncology
About Us
Why Our Lab
Sirona Dx is a technical CRO, founded to accelerate the pace of targeted therapy development. Bridging silos between diagnostics manufacturers and translational clinical research our clinical service laboratory offers specialized high complexity genomics and proteomics services supporting pharmaceutical companies with their drug discovery and development programs.
How We Help
Sirona Dx operates a CLIA certified facility and collaborates with leading platform providers including ThermoFisher, illumina, Fluidigm and nanoString to secure early access to advanced technologies. We offer a comprehensive menu of high parameter immuno oncology expression profiling assays to explore tumor immunobiology and identify new biomarkers. immunotherapy CRO
Experience the Difference
Our experienced team offers expertise for clinical protocol design combined with a variety of customized reporting, clinical trial site training, and investigator support.
We have the industry's most comprehensive offering of Mass Cytometry and Imaging Mass Cytometry assays and our leading expertise in the extraction of RNA from challenging sample types including FFPE enabling our pharma clients to profile more of their precious samples. immuno oncology immunotherapy