SironaDx
SironaDx
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    • Home
    • Platforms
      • Imaging Mass Cytometry
      • CyTOF Mass Cytometry
      • Next Gen. Sequencing
      • Capillary Electophoresis
      • Quantitative RT- PCR
      • NanoString nCounter
    • Services
      • Services overview
      • IMC/Multiplexed IHC
      • CyTOF Mass Cytometry
      • Human Immune Monitoring
      • Targeted Seq. Panels
      • I-O Expression Assay
      • Oncomine Focus
      • Cancer HSM Panel
      • Disease Sp. Cancer Panels
    • About Us
    • News & Events
    • Contact Us
    • COVID-19 Testing
  • Home
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  • About Us
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  • Contact Us
  • COVID-19 Testing

The I-O Clinical Service Laboratory

The I-O Clinical Service Laboratory The I-O Clinical Service Laboratory

Accelerating Therapeutic Development with Advanced Single Cell Services Including Spatialomics

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About Us

Sirona Dx is a CLIA accredited technical CRO, providing advanced, high complexity, single cell proteomics and genomics services to accelerate the pace of immunotherapy and targeted therapy development.  


In contrast to most CROs, we embrace leading edge technologies at an earlier stage, often assisting life science companies with product development.  Bridging silos between tools developers and biopharma means our clients access enabling technologies and expertise sooner and within a CLIA accredited laboratory that supports pharma regulatory requirements.  Our team can assist with platform selection and with the design, optimization and validation of complex multi-analyte assays. 


Harness breakthrough technologies to profile and integrate biology with single-cell resolution including tissue spatial context to reveal the next generation of precision biomarker signatures to accelerate therapies towards regulatory approval.   


Recognized as the original pioneers of spatial biology we launched the first spatial-omics CRO service in 2018 utilizing IMC technology developed by Fluidigm.  Today our technology agnostic, spatial biology suite includes the leading multiplexed imaging platforms.  Our team can develop panels of up to 49 markers to reveal the complex interplay between the immune system and the tumor/tissue microenvironment.  


We leverage CyTOF technology from Fluidigm to perform ultradeep immune profiling of whole blood and PBMCs with highly multiplexed assays of 40+ markers.  


High performance RNA extraction methodologies coupled with a comprehensive menu of high parameter IO expression profiling assays supports exploration of complex tumor immunobiology from challenging sample types.  


From exploratory testing and biomarker development through to clinical trials support, we partner with you every step of the way.


Contact us with your specific requirements and our team will guide you to the optimal assays and platforms to support your study.


What Makes Us Unique?

Sirona Dx is a CLIA accredited technical CRO, founded in 2016 to accelerate the pace of immunotherapy and targeted therapy development. Bridging silos between life science tools developers and translational clinical research, our laboratory offers specialized high complexity single cell proteomics and genomics services to support biopharma drug discovery and development programs.

In contrast to most CROs, we embrace technologies at an early stage, assisting life science companies with product development. Our pharma clients benefit from early access to leading edge technologies along with the technical expertise to harness them. All of this within a CLIA accredited laboratory that supports pharma regulatory requirements.

Imaging mass cytometry service with Hyperion Imaging System for mIHC single cell spatial-omics

How We Help Biopharma

Our experienced team can assist with platform selection, assay design and optimization, validation and deployment of complex multi-analyte assays to accelerate therapies towards regulatory approval.

Harness breakthrough technologies to profile and integrate biology with single-cell resolution including tissue spatial context to reveal the next generation of precision biomarker signatures.  

From exploratory testing and biomarker development through to clinical trials support, we partner with you every step of the way. 

January 2022

Sirona Dx - A Top 10 CRO of 2021

Sirona Dx was selected as a Top 10 CRO of 2021 by Medhealth Outlook on the basis of our leading-edge service capabilities for single cell proteomics and spatialomics. Read more at: https://medhealthoutlook.com/sirona-dx/

Featured platforms and services

immune profiling service using CyTOF with Helios system

CyTOF® & Imaging Mass Cytometry (IMC™)

We utilize Mass Cytometry platforms from Fluidigm to support high parameter protein profiling assays of individual cells in suspension (Helios™) as well as multiplex tissue imaging (Hyperion™). 

We utilize state-of-the-art CyTOF technology to help you maximize results from precious samples and translate new discoveries into better clinical outcomes.


Immune Portrait™ TME 34+5

An optimized IMC panel that enables comprehensive analysis of the tumor microenvironment at a sub-cellular resolution. Use as is, or modify to accelerate the development of a custom panel.
Panel features:

  • 34 tumor and immune cell markers
  • Identify Stromal and Vascular cells, Adaptive and innate Immune cells                            
  • Includes markers for immune checkpoint proteins and T cell exhaustion 
  • Add up to 5 additional markers of your choice and/or delete non-essential markers to create a custom panel to match your project requirements.

Multiplexed RNA, miRNA & DNA, Single Molecule Counting with NanoString's Digital Barcoding Technology

The nCounter® platform provides a cost-effective solution for  multiplex analysis of up to 800 RNA, miRNA, DNA, or protein targets, without amplification, cDNA conversion or library prep

Targeted Sequencing

Sirona Dx is an Ion Torrent Certified Service Provider, offering an  extensive suite of Next Generation Sequencing capabilities with the Ion PGM system.

Targeted sequencing enables the interrogation of specific genomic regions in a high throughput and cost-effective manner


Rapid, Low Cost, PCR Based COVID-19 Surveillance Testing

  • Low cost PCR based COVID-19 test
  • Fluidigm COVID-19 test
  • PCR based COVID-19 testing service
  • Saliva based COVID-19 test
  • Low cost PCR based COVID-19 test
  • Fluidigm COVID-19 test
  • PCR based COVID-19 testing service
COVID-19 PCR testing service

COVID-19 PCR Testing Service

  • Advanced microfluidics technology enables rapid, accurate, low cost COVID-19 testing on easy to collect saliva samples.     
  • Ideal for work place surveillance screening. 
  • Test results available within 24h after arrival at our Portland, Oregon based clinical laboratory. 

Contact us to Learn More

COVID-19 Testing Services and Support for COVID-19 Vaccine D

SARS-Cov-2

SARS-CoV-2 PCR Test for COVID-19

Sirona Dx collaborated with Fluidigm to offer a faster, more accurate and non-invasive RNA testing service for COVID-19 infection. 

Leveraging the power of microfluidics our saliva based assay enables rapid testing of thousands of samples per day with increased accuracy and at a lower cost.  

If you need access to COVID-19 testing, please contact us for more information.

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COVID-19

COVID-19 Vaccine & Drug Development

Understanding the immune response in COVID-19 patients can help direct the development of new therapeutics and vaccines. Our scientists leverage Mass Cytometry and Imaging Mass Cytometry to analyze immune cell frequencies and activation states in patients blood and lung tissue. Please contact us for more information.

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info@sironadx.com

SironaDx

4640 Southwest Macadam Avenue, Portland, Oregon 97239, United States

(503) 919-8919

Hours

Monday - Friday: 8:00am - 6:00pm PST

Saturday - Sunday: Closed

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