The I-O Clinical Service Laboratory

The I-O Clinical Service Laboratory

The I-O Clinical Service Laboratory The I-O Clinical Service Laboratory The I-O Clinical Service Laboratory

Find out how we can accelerate your drug discovery and development programs

our mission

To Accelerate the Pace of Cancer Immunotherapy and Targeted Therapy Development by:

•Bridging the Divide Between Pharma and Advanced Life Science Tools Companies

••Deriving Maximum Information from each Sample Utilizing Advanced Multiplex Platforms

•••Optimizing Sample Quality & Supporting Pharma Regulatory Requirements within Our CLIA Laboratory

Our Services



Featured Platforms & Services


Mass Cytometry (CyTOF®) and Imaging Mass Cytometry (IMC™)


We have embraced mass cytometry platforms from Fluidigm to support high parameter protein profiling assays of individual cells in suspension (Helios™) as well as multiplex tissue imaging (Hyperion™). 

We utilize state-of-the-art CyTOF technology to help you maximize results from precious samples and translate new discoveries into better clinical outcome!

Immune Portrait™ TME 34+5


The World’s First and Only Full Service Imaging Mass Cytometry (IMC) I-O panel that enables comprehensive analysis of the tumor microenvironment (TME):
• Visualize 34-biomarker in a single tissue section.
• Simultaneously identify Stromal & Vascular cells, Adaptive Immune cells and Innate Immune cells.  
• Profile markers for immune checkpoint proteins, T cell exhaustion and functional state markers.
• Customizable – add 5 markers of your choice


NanoStrings Multiplexed RNA, miRNA & DNA, Single Molecule Counting with Digital Barcodes Technology


The nCounter® platform provides a  cost-effective solution for  multiplex analysis of up to 800 RNA, miRNA, DNA, or protein targets. without amplification, cDNA conversion or library prep. immuno oncology

Targeted Sequencing


Sirona Dx is an Ion Torrent Certified Service Provider, offering an  extensive suite of Next Generation Sequencing capabilities with the Ion  PGM and Proton systems.

Targeted sequencing enables the interrogation of specific genomic regions in a high throughput and cost-effective manner. immuno oncology

About Us

Why Our Lab


Sirona Dx is a technical CRO, founded to accelerate the pace of targeted therapy development. Bridging silos between diagnostics manufacturers and translational clinical research our clinical service laboratory offers specialized high complexity genomics and proteomics services supporting pharmaceutical companies with their drug discovery and development programs. 

How We Help


Sirona Dx operates a CLIA certified facility and collaborates with leading platform providers including ThermoFisher, illumina, Fluidigm and nanoString to secure early access to advanced technologies. We offer a comprehensive menu of high parameter immuno oncology expression profiling assays to explore tumor immunobiology and identify new biomarkers. immunotherapy CRO

Experience the Difference


Our experienced team offers expertise for clinical protocol design combined with a variety of customized reporting, clinical trial site training, and investigator support. 

We have the industry's most comprehensive offering of Mass Cytometry and Imaging Mass Cytometry assays and our leading expertise in the extraction of RNA from challenging sample types including FFPE enabling our pharma clients to profile more of their precious samples. immuno oncology immunotherapy

Contact Us

Please send us a message or call us for an appointment.


4640 Southwest Macadam Avenue, Portland, Oregon 97239, United States

(503) 919-8919


Monday - Friday: 8:00am - 6:00pm PST

Saturday - Sunday: Closed

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