The I-O Clinical Service Laboratory
Advanced single cell, multi-omic approaches to accelerate your drug discovery and development programs
About Us
Sirona Dx is a technical CRO, founded to accelerate the pace of targeted therapy development. Bridging silos between diagnostics manufacturers and translational clinical research our clinical service laboratory offers early access to specialized high complexity single cell proteomics and genomics services supporting pharmaceutical companies with their drug discovery and development programs. From exploratory testing and biomarker development through to clinical trials support, we partner with you every step of the way.
What Makes Us Unique?
Sirona Dx is a CLIA accredited technical CRO, founded in 2016 to accelerate the pace of immunotherapy and targeted therapy development. Bridging silos between life science tools developers and translational clinical research, our laboratory offers specialized high complexity single cell proteomics and genomics services to support biopharma drug discovery and development programs.
In contrast to most CROs, we embrace technologies at an early stage, assisting life science companies with product development. Our pharma clients benefit from early access to leading edge technologies along with the technical expertise to harness them. All of this within a CLIA accredited laboratory that supports pharma regulatory requirements.
How We Help Biopharma
Our experienced team can assist with platform selection, assay design and optimization, validation and deployment of complex multi-analyte assays to accelerate therapies towards regulatory approval.
Harness breakthrough technologies to profile and integrate biology with single-cell resolution including tissue spatial context to reveal the next generation of precision biomarker signatures.
From exploratory testing and biomarker development through to clinical trials support, we partner with you every step of the way.
Featured platforms and services
CyTOF® & Imaging Mass Cytometry (IMC™)
We utilize Mass Cytometry platforms from Fluidigm to support high parameter protein profiling assays of individual cells in suspension (Helios™) as well as multiplex tissue imaging (Hyperion™).
We utilize state-of-the-art CyTOF technology to help you maximize results from precious samples and translate new discoveries into better clinical outcomes.
Immune Portrait™ TME 34+5
An optimized IMC panel that enables comprehensive analysis of the tumor microenvironment at a sub-cellular resolution. Use as is, or modify to accelerate the development of a custom panel.
Panel features:
- 34 tumor and immune cell markers
- Identify Stromal and Vascular cells, Adaptive and innate Immune cells
- Includes markers for immune checkpoint proteins and T cell exhaustion
- Add up to 5 additional markers of your choice and/or delete non-essential markers to create a custom panel to match your project requirements.
Multiplexed RNA, miRNA & DNA, Single Molecule Counting with NanoString's Digital Barcoding Technology
The nCounter® platform provides a cost-effective solution for multiplex analysis of up to 800 RNA, miRNA, DNA, or protein targets, without amplification, cDNA conversion or library prep
Targeted Sequencing
Sirona Dx is an Ion Torrent Certified Service Provider, offering an extensive suite of Next Generation Sequencing capabilities with the Ion PGM system.
Targeted sequencing enables the interrogation of specific genomic regions in a high throughput and cost-effective manner
Rapid, Low Cost, PCR Based COVID-19 Surveillance Testing
COVID-19 PCR Testing Service
- Advanced microfluidics technology enables rapid, accurate, low cost COVID-19 testing on easy to collect saliva samples.
- Ideal for work place surveillance screening.
- Test results available within 24h after arrival at our Portland, Oregon based clinical laboratory.
COVID-19 Testing Services and support for COVID-19 Vaccine a
SARS-CoV-2 PCR Test for COVID-19
Sirona Dx collaborated with Fluidigm to offer a faster, more accurate and non-invasive RNA testing service for COVID-19 infection.
Leveraging the power of microfluidics our saliva based assay enables rapid testing of thousands of samples per day with increased accuracy and at a lower cost.
If you need access to COVID-19 testing, please contact us for more information.
COVID-19 Vaccine & Drug Development
Understanding the immune response in COVID-19 patients can help direct the development of new therapeutics and vaccines. Our scientists leverage Mass Cytometry and Imaging Mass Cytometry to analyze immune cell frequencies and activation states in patients blood and lung tissue. Please contact us for more information.
October 2020
Sirona Dx - A Top 10 Drug Discovery and Development Service
Sirona Dx was selected as one of the Top 10 Drug Discovery and Development Service Companies for 2020 by Pharma Tech Outlook Magazine.
Today, over 30 pharma and biotech clients rely on Sirona Dx to advance their immune therapy assets. Read more at: https://lnkd.in/g2tgj2d