SironaDx
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    • Home
    • Platforms
      • Imaging Mass Cytometry
      • CyTOF Mass Cytometry
      • Next Gen. Sequencing
      • Capillary Electophoresis
      • Quantitative RT- PCR
      • NanoString nCounter
    • Services
      • Services overview
      • IMC/Multiplexed IHC
      • CyTOF Mass Cytometry
      • Human Immune Monitoring
      • Targeted Seq. Panels
      • IO Expression Assays
      • Oncomine Focus
      • Cancer HSM Panel
      • Disease Sp. Cancer Panels
      • Histopathology
    • About Us
    • News & Events
    • Contact Us
    • COVID-19 Testing
  • Home
  • Platforms
  • Services
  • About Us
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  • Contact Us
  • COVID-19 Testing

The I-O Clinical Service Laboratory

The I-O Clinical Service Laboratory The I-O Clinical Service Laboratory

Accelerating Therapeutic Development with Advanced Single Cell 

Services Including Spatialomics

Contact Us To Learn More

Sirona Dx is a CLIA accredited technical CRO, providing advanced, high complexity, single cell proteomics and genomics services to accelerate the pace of immunotherapy and targeted therapy development.  


In contrast to most CROs, we embrace leading edge technologies at an earlier stage, often assisting life science companies with product development.  Bridging silos between tools developers and biopharma means our clients access enabling technologies and expertise sooner and within a CLIA accredited laboratory that supports pharma regulatory requirements.  Our team can assist with platform selection and with the design, optimization and validation of complex multi-analyte assays. 


Harness breakthrough technologies to profile and integrate biology with single-cell resolution including tissue spatial context to reveal the next generation of precision biomarker signatures.   


Recognized as the original pioneers of spatial biology we launched the first spatial-omics CRO service in 2018 utilizing IMC technology developed by Fluidigm.  Today our technology agnostic, spatial biology suite includes the leading multiplexed imaging platforms.  Our team can develop panels of up to 49 markers to reveal the complex interplay between the immune system and the tumor/tissue microenvironment.  


We leverage CyTOF technology from Fluidigm to perform ultradeep immune profiling of whole blood and PBMCs with highly multiplexed assays of up to 45 markers.  


High performance RNA extraction methodologies coupled with a comprehensive menu of high parameter IO expression profiling assays supports exploration of complex tumor immunobiology from challenging sample types.  


From exploratory testing and biomarker development through to clinical trials support, we partner with you every step of the way.


Contact us with your specific requirements and our team will guide you to the optimal assays and platforms to support your study.


What Makes Us Unique?

Sirona Dx is a CLIA accredited technical CRO, founded in 2016 to accelerate the pace of immunotherapy and targeted therapy development with innovative, high complexity single cell proteomics and genomics services.

In contrast to most CROs, we embrace technologies at an early stage, assisting life science companies with product development. Our pharma clients benefit from early access to leading edge technologies along with the technical expertise to harness them. All of this within a CLIA accredited laboratory that supports pharma regulatory requirements.

How We Help Biopharma

Our experienced team can assist with platform selection, assay design and optimization, validation and deployment of complex multi-analyte assays to accelerate therapies towards regulatory approval.

Harness breakthrough, leading edge technologies to profile and integrate biology with single-cell resolution including tissue spatial context to reveal the next generation of precision biomarker signatures.  

From exploratory testing and biomarker development through to clinical trials support, we partner with you every step of the way. 

January 2022

A Top 10 CRO of 2021

Sirona Dx was selected as a Top 10 CRO of 2021 by Medhealth Outlook on the basis of our leading-edge service capabilities for single cell proteomics and spatialomics. Read more at: https://medhealthoutlook.com/sirona-dx/

Featured platforms and services

immune profiling service using CyTOF with Helios system

CyTOF® & Imaging Mass Cytometry (IMC)

We utilize Mass Cytometry platforms from Fluidigm to support high parameter protein profiling assays of individual cells in suspension (Helios™) as well as multiplex tissue imaging (Hyperion™). 

We utilize state-of-the-art CyTOF technology to help you maximize results from precious samples and translate new discoveries into better clinical outcomes.


Immune Portrait™ TME Multiplexed Imaging Assay

An optimized IMC panel that enables comprehensive analysis of the tumor microenvironment at a sub-cellular resolution.
Panel features:

  • 34 tumor and immune cell markers
  • Identify Stromal and Vascular cells, Adaptive and innate Immune cells                            
  • Includes markers for immune checkpoint proteins and T cell exhaustion 
  • Add up to 5 additional markers of your choice and/or delete non-essential markers to create a custom panel to match your project requirements.

Multiplexed RNA, miRNA & DNA, Single Molecule Counting with NanoString's Digital Barcoding Technology

The nCounter® platform provides a cost-effective solution for  multiplex analysis of up to 800 RNA, miRNA, DNA, or protein targets, without amplification, cDNA conversion or library prep

Targeted Sequencing

Sirona Dx is an Ion Torrent Certified Service Provider, offering an  extensive suite of Next Generation Sequencing capabilities with the Ion PGM system.

Targeted sequencing enables the interrogation of specific genomic regions in a high throughput and cost-effective manner


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info@sironadx.com

SironaDx

4640 Southwest Macadam Avenue, Portland, Oregon 97239, United States

(503) 919-8919

Hours

Monday - Friday: 8:00am - 6:00pm PST

Saturday - Sunday: Closed

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